Depo-Provera vs Depo-SubQ Provera 104 — Which Injections Qualify for a Claim

Depo-SubQ Provera 104 is a prescription birth control shot now at the center of a growing wave of brain tumor lawsuits. This page explains what those claims involve. It also covers how the injection differs from the standard Depo-Provera shot. Thousands of women say long-term use caused a type of tumor called meningioma. As a result, many are now asking whether their specific injections qualify for a legal claim. Understanding the difference between the two formulations matters more than most people expect.

What Is the Depo-SubQ Provera 104 Lawsuit About?

The lawsuits target medroxyprogesterone acetate, the active hormone in these injections. Pfizer, through its Pharmacia & Upjohn unit, makes both versions. Depo-SubQ Provera 104 delivers 104 mg of the hormone under the skin. The older Depo-Provera CI shot delivers 150 mg into the muscle. However, both use the same active drug and carry the same core warning.

Plaintiffs allege that repeated use raised their risk of meningioma. A meningioma is a tumor that grows in the membranes around the brain or spine. Most are noncancerous. Even so, they can cause serious harm. For example, patients may need brain surgery, radiation, or ongoing monitoring. Some suffer vision loss, seizures, or lasting neurological damage.

The science shifted in January 2026. The FDA approved a labeling update warning that these injections may increase meningioma risk. Importantly, that warning applies to both Depo-Provera CI and Depo-SubQ Provera 104. Lawsuits argue the company knew or should have known about this risk years earlier. Plaintiffs say adequate warnings were never provided to patients or doctors.

MDL Case Status and Key Facts

The federal cases are consolidated into one multidistrict litigation, or MDL. This lets one judge manage shared pretrial issues efficiently. The litigation has grown quickly through 2026. Below are the key facts as reported in official court filings.

The case count rose sharply in spring 2026. The June JPML report showed thousands of pending claims. By July 1, filings approached roughly 5,900. As a result, this is now one of the faster-growing pharmaceutical MDLs in the country.

A major development arrived on June 15, 2026. Judge Rodgers entered an order noting a global settlement in principle. The general-causation (Daubert) hearing was reset to July 27, 2026. Meanwhile, the first bellwether trial deadlines were vacated. Details are still being finalized, so figures remain unconfirmed.

Who Qualifies for a Depo-SubQ Provera 104 Claim?

Eligibility depends on your specific medical history. Law firms typically look for a few core factors. First, you must have an image-confirmed meningioma diagnosis. That means an MRI or CT scan showing the tumor. Self-reported symptoms alone are not enough.

Second, you must have used the product over time. In most cases, firms look for repeated injections across roughly a year or more. Using Depo-SubQ Provera 104 at least twice is a common threshold. Authorized generic versions may also count. Typically, longer use strengthens a potential claim.

Third, evidence matters. You will likely need pharmacy records, prescription history, and imaging reports. Proof of treatment helps too. For example, surgery, radiation, or a scheduled procedure supports the claim. However, only a licensed attorney can confirm whether your Depo-SubQ Provera 104 history qualifies. You may be eligible even if you also used the standard shot.

How to File a Depo-SubQ Provera 104 Claim

Filing follows a fairly standard process. Start by gathering your records. Collect prescription dates, pharmacy printouts, and imaging results. These documents build the foundation of any claim. The more complete they are, the better.

Next, consult a licensed attorney who handles mass tort cases. Most offer free case reviews. If they accept your case, they typically file it into MDL No. 3140 or an appropriate state court. You will likely complete a plaintiff fact sheet. This form details your medical and product history under oath.

Timing is critical. Statutes of limitations vary by state. In some places, the window may be as short as one year from diagnosis. As a result, waiting can permanently bar a claim. For this reason, speak with a lawyer promptly if you believe you might be eligible.

Settlement Updates and What to Expect

The June 2026 settlement in principle is significant. However, it is not final. It does not cover every case. It also does not automatically resolve state court claims. Both sides are still finalizing terms as of July 2026.

Compensation amounts remain unconfirmed. Individual payouts in mass torts generally vary widely. Several factors typically influence value. These include tumor severity, the type of treatment required, and total duration of use. Age and lasting disability can also matter. No one can promise a specific figure.

Timelines in these cases can stretch out. Even after a framework is announced, claim review takes time. For example, plaintiffs often submit documentation for individual assessment. In most cases, stronger evidence supports a stronger claim. You may qualify for compensation, but nothing is guaranteed. An attorney can give you a realistic picture based on your facts.

State-by-State Considerations

State law shapes these claims in important ways. Tort reform rules differ across the country. Some states cap certain damages. Others set shorter filing deadlines. These differences can affect both eligibility and value.

Large plaintiff populations tend to cluster in bigger states. For example, California, Texas, Florida, New York, and Pennsylvania often see high filing volumes. State court options may exist alongside the federal MDL. However, the right venue depends on your residence and injury location. A licensed attorney can review your state’s rules and pick the best path for your Depo-SubQ Provera 104 claim.

Frequently Asked Questions

Is Depo-SubQ Provera 104 different from the regular Depo-Provera shot?

Yes, but they share the same active hormone. Depo-SubQ Provera 104 uses 104 mg injected under the skin. The standard shot uses 150 mg into the muscle. The 2026 meningioma warning applies to both.

Do I qualify if I only used Depo-SubQ Provera 104 a few times?

It depends on your records and diagnosis. Firms typically look for repeated use and an image-confirmed meningioma. Even limited use may matter in some cases. A licensed attorney can evaluate your specific history.

How long do I have to file a claim?

Deadlines vary by state and can be short. In some places, the limit may be about one year from diagnosis. Missing it can bar your claim entirely. For this reason, consult an attorney quickly.

Check If You May Qualify

Mass tort eligibility depends on your specific exposure, injuries, and the state where you live. A licensed mass tort attorney can evaluate your situation at no upfront cost — most work on contingency, meaning you pay nothing unless you recover compensation.

Official Sources & Resources

For verified mass tort and MDL information:

• JPML: jpml.uscourts.gov — official MDL statistics and transfer orders
• DOJ: justice.gov — settlement announcements and press releases
• FDA: fda.gov — drug recalls, warning letters, and safety alerts
• CDC: cdc.gov — health condition data and exposure guidelines
• EPA: epa.gov — environmental contamination data
• Cornell LII: law.cornell.edu — plain-English legal definitions

Content last reviewed July 2026. This is general educational information, not legal advice. If you notice outdated information, please contact us.

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• Florida Tort Reform Guide
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Attorney Advertising. The information on this page is provided for general informational purposes only and does not constitute legal advice. No attorney-client relationship is created by accessing or using this content. Every case is unique, and results depend on the specific facts and circumstances involved. Past settlement amounts and case outcomes do not guarantee similar results in your case. If you believe you have a legal claim, you should consult with a licensed attorney in your jurisdiction who can evaluate your specific situation.